Synergism is defined as

Synergism is defined as

• A. The combined effect equals the sum of individual effects
• B. The combined effect is less than the sum of individual effects
• C. No interaction between the drugs
• D. The combined effect is greater than the sum of individual effects

Answer: (D)

Synergism occurs when two drugs interact to produce a combined effect that is greater than the sum of their individual effects. This means the overall response from using them together exceeds what you would expect by simply adding each one's effect. If the combined effect equals the sum, that’s additive; if it’s less than the sum, that’s antagonistic; if there’s no interaction, they act independently. Synergy often arises when the drugs affect different targets or one enhances the other's activity or concentration, leading to a bigger total impact. For example, two antimicrobials that block separate steps in bacterial cell wall synthesis can produce a higher bactericidal effect together than either would alone.

Synergism occurs when two drugs interact to produce a combined effect that is greater than the sum of their individual effects. This means the overall response from using them together exceeds what you would expect by simply adding each one's effect. If the combined effect equals the sum, that’s additive; if it’s less than the sum, that’s antagonistic; if there’s no interaction, they act independently. Synergy often arises when the drugs affect different targets or one enhances the other's activity or concentration, leading to a bigger total impact. For example, two antimicrobials that block separate steps in bacterial cell wall synthesis can produce a higher bactericidal effect together than either would alone.