Desensitization is reversible after the removal of the stimulating drug. Which statement is true?

Desensitization is reversible after the removal of the stimulating drug. Which statement is true?

• A. Yes, it is irreversible.
• B. Yes, it is reversible after removal of the drug.
• C. No, it cannot be reversed.
• D. It depends on the receptor type.

Answer: (B)

Desensitization is a pharmacodynamic change where repeated exposure to a drug reduces the cell’s response. When the stimulating drug is removed, the system can reset: receptors can recycle back to the membrane or new receptors can be made, signaling pathways recover, and sensitivity returns. This makes desensitization generally reversible after withdrawal of the drug. Some systems may resensitize more slowly or show longer-lasting changes, but the common principle is that removing the stimulus allows the response to come back.

Desensitization is a pharmacodynamic change where repeated exposure to a drug reduces the cell’s response. When the stimulating drug is removed, the system can reset: receptors can recycle back to the membrane or new receptors can be made, signaling pathways recover, and sensitivity returns. This makes desensitization generally reversible after withdrawal of the drug. Some systems may resensitize more slowly or show longer-lasting changes, but the common principle is that removing the stimulus allows the response to come back.